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Anthony Yan

Photo: Anthony Yan

I'm interested in solving problems in biochemistry by using algorithms with provable guarantees. My current research is focused on protein structure determination using nuclear magnetic resonance (NMR) data.

Donald Lab Graphic

In particular I'm interested in applying data from residual dipolar couplings (RDCs) and the nuclear Overhauser efffect (NOEs). To do this, I use ideas related to configuration space, inverse kinematics, and computational geometry to obtain provably complete ensembles of protein structures. Additional interests include protein flexibility, entropy, denatured structures, NMR assignment, mass spectroscopy, and X-ray crystallography.


  1. Structure Determination of Symmetric Homo-oligomers by a Complete Search of Symmetry Configuration Space Using NMR Restraints and van der Waals Packing. S. Potluri, A. Yan, J. Chou, B. R. Donald, and C. Bailey-Kellogg. Proteins 2006; 65(1):203-219.
  2. A Complete Algorithm to Resolve Ambiguity for Inter-subunit NOE Assignment in Structure Determination of Symmetric Homo-oligomers. S. Potluri, A. Yan, and C. Bailey-Kellogg. Protein Science 2006; In press.