Open-Source
Our software is
Free software
Dlab software:
OSPREY
DISCO
PIV
LibProtNMR
ConDIOs
RDC-PANDA
NASCA
POOL
Q5
CRANS
Software previously released by the Donald Lab:
Exact-2NH
MTC
NVR/HD/GD
Rage/Enrage
Software Developed by the Donald Lab
HASH
Welcome to the website for the HASH software. Here, you can download the newest version of the software, read the license agreement, or e-mail inquiries. Instructions for installing and using HASH can be found in the README file included in the distribution.
HASH is an automated program for predicting Ha chemical shifts using the chemical shifts of nearby backbone atoms (i.e., adjacent atoms in the sequence). HASH is developed in the lab of Prof. Bruce Donald at Duke University.
The current version of HASH specifically exploits the dependencies on chemical shifts of nearby backbone atoms to predict Ha chemical shifts. It combines a new fragment-based chemical shift search approach with a non-parametric regression model, called the generalized additive model, to effectively solve the prediction problem. More details about HASH can be found in our primary publications:
- Jianyang Zeng, Pei Zhou, Bruce R. Donald. HASH: a program to accurately predict protein Ha shifts from neighboring backbone shifts. Journal of Biomolecular NMR, Dec 16, 2012. [Epub ahead of print]
HASH is free software and can be redistributed and/or modified under the terms of the GNU Lesser General Public License as published by the Free Software Foundation, either version 3 of the License, or (optionally) any later version. HASH is distributed in the hope that they will be useful, but WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the GNU Lesser General Public License for more details. Full licensing details, including citation requirements for the various different modules of the software, are found here.